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max) that didn't outcome from reduced plasma membrane expression, diminished potency, or binding capacity on the transporter. We also uncovered reductions in the amount of five-HT synapses in the midbrain, Though no changes in SERT protein ranges have been noticed in tissue or synaptosomes isolated from KI mice in comparison with WT preparations, indicating compensatory effects at the neuron degree.
), suggesting that constitutive activation of integrin β3 decreases the Affiliation of SERT with integrin adhesion complexes.
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